Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase

<div>LPS-induced protein levels of NLRP3 and cleaved caspase-1 expression in RAW264.7 cells pretreated with different concentrations of CORT. After pretreatment with different concentrations of CORT for 1 h, the cells were stimulated with LPS (1 <i>μ</i>g/ml) for an additional 1 h. (a) Western blots showing NLRP3 and cleaved caspase-1 expression. (b) Statistical chart showing the relative expression of NLRP3 protein. (c) Statistical chart showing the relative expression of cleaved caspase-1 protein. Values are mean (s.d.) 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase 