Research Article
Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells
Figure 3
Dexmedetomidine inhibited gap junction function and Cx43 expression on HUVECs. (a) Effects of dexmedetomidine (Dexm: 0.1 nM and 1 nM, 24 hours) on dye coupling on HUVECs (, vs. control; # vs. 0.1 nM group). (b) Effects of dexmedetomidine (Dexm: 0.1 nM and 1 nM, 24 hours) on Cx43 expression on HUVECs (, vs. control; # vs. 0.1 nM group). In all experiments, HUVECs were all pretreated with TNF-α (10 ng/ml, 12 h). Effects of TNF-α are showed in Supplemental Figure 1.
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