The Role of MIF-173G/C Gene Polymorphism in the Susceptibility of Autoimmune Diseases

Table 1

Characteristics of the included studies.

First author	Year	Disease	Country	Area	Method	Case			Control
						GG	GC	CC	GG	GC	CC
Alfonso	2007	RA	Mexico	North America	PCR-RFLP	431	157	18	681	188	18	0.24
Assis (1)	2014	AIH	America	Europe	ELISA	31	13	1	219	63	4	0.83
Assis (2)	2014	PBC	America	Europe	ELISA	215	82	7	219	63	4	0.83
Fei (1)	2008	UC	China	Asia	PCR-RFLP	44	27	13	79	55	8	0.7
Fei (2)	2008	CD	China	Asia	PCR-RFLP	8	5	2	79	55	8	0.7
Nunez	2007	CD	Spain	Europe	NA	372	149	10	681	188	18	0.24
Çevik	2016	AS	Turkey	Europe	RFLP	116	42	3	136	49	9	0.11
Zhan	2013	VKH	China	Asia	PCR-RFLP	360	226	14	417	167	16	0.88
David (1)	2016	AIH	Japan	Asia	ELISA	36	14	2	18	12	0	0.17
David (2)	2016	AIH	America	Europe	ELISA	37	15	1	18	12	0	0.17
Sanchez	2006	SLE	Spain	Europe	PCR-RFLP	503	175	33	570	171	14	0.78
Wang	2013	AOSD	China	Asia	PCR-RFLP	69	26	5	157	42	1	0.31
Wu	2009	Ps	China	Asia	PCR-RFLP	137	94	9	163	95	8	0.8
Jung	2016	AD	Korea	Asian	PCR-RFLP	117	51	10	61	18	1	0.18
Karolina (1)	2011	UC	Poland	Europe	PCR-RFLP	38	19	1	99	23	1	0.79
Karolina (2)	2011	CD	Poland	Europe	PCR-RFLP	28	12	1	99	23	1	0.79
Larissa	2006	RA	Germany	Europe	PCR	90	24	5	160	59	6	0.84
Ma	2013	AD	China	Asia	NA	93	65	15	136	75	7	0.39
M.A.	2013	RA	Mexico	North America	PCR-RFLP	43	49	8	53	42	5	0.36
Wu	2006	SD	America	Europe	ELISA	105	47	7	149	72	6	0.44
Timothy	2005	RA	Holland	Europe	PCR	188	71	11	198	69	10	0.20
Zheng	2012	BD	China	Asia	PCR-RFLP	359	212	29	417	167	16	0.88
Hao (1)	2015	HSPN	China	Asia	PCR-RFLP	3	8	20	8	15	7	1.00
Hao (2)	2015	HSPN	China	Asia	PCR-RFLP	5	11	24	10	14	6	0.79
Ruan	2014	UC	China	Asia	NA	99	61	5	124	69	6	0.33
Xie	2007	RA	China	Asia	PCR	28	10	5	19	8	3	0.16
Zhang (1)	2014	HSP	China	Asia	PCR-RFLP	2	7	16	5	13	7	0.82
Zhang (2)	2014	HSP	China	Asia	PCR-RFLP	2	8	15	10	14	6	0.79
Zhuang	2014	PG	China	Asia	PCR-RFLP	18	9	3	190	114	9	0.09

RA: rheumatoid arthritis; AIH: autoimmune hepatitis; PBC: primary biliary cirrhosis; UC: ulcerative colitis; CD: Crohn’s disease; AS: ankylosing spondylitis; VKH: Vogt-Koyanagi-Harada syndrome; SLE: systemic lupus erythematosus; AOSD: adult Still disease; Ps: psoriasis; AD: atopic dermatitis; SD: scleroderma; BD: Behcet’s disease; HSPN: Henoch-Schonlein purpura nephritis; HSP: Henoch-Schonlein purpura; PG: primary gout; PCR-RFLP: Polymerase Chain Reaction-Restriction Fragment Length Polymorphism; PCR: Polymerase Chain Reaction; NA: not available.