Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis

Table 1

Clinical characteristics of patients with DM.

Characteristics	Patients with DM; % (/) or /median (IQR)
Female/male ratio	108/42
Onset age (yrs, )
Disease duration (months, median (IQR))	8.5 (2.4-24)
Treatment naïve	32% (48/150)
Clinical features
Muscle weakness	66.7% (100/150)
Myalgia	39.3% (59/150)
Heliotrope sign	50.7% (76/150)
Gottron papules	58.7% (88/150)
Mechanic’s hands	33.3% (50/150)
Raynaud phenomenon	7.3% (11/150)
Skin ulcer	19.3% (29/150)
Arthritis/arthralgia	32% (48/150)
Dysphagia	27.3% (41/150)
ILD	68% (102/150)
RP-ILD	19.3% (29/150)
Malignancy	15.3% (23/150)
Laboratory examinations
ANA-positive	32.9% (47/143)
Anti-ARS	20.7% (31/150)
Anti-MDA-5	26% (39/150)
Anti-TIF1γ	13.3% (20/150)
Anti-NXP2	5.3% (8/150)
Anti-Mi-2	5.3% (8/150)
Anti-SAE	2% (3/150)
MSA negative	27.3% (41/150)
CK levels (26-200 IU/l)	80 (37-253)
LDH levels (100-250 IU/l)^a	237 (183-342.5)
CRP levels (<0.8 mg/dl)^b	0.518 (0.187-1.158)
ESR levels (<20 mm/H)^c	15 (7-38.25)
Ferritin levels (11-306.8 ng/ml)^d	208.8 (87.65-604.9)
IgG (694-1620 mg/dl)^e	1210 (1003-1480)
CD3+ T cell percentage (50.7-86%)^f	70.7 (64.93-80.13)
CD4+ T cell percentage (23.3-50.2%)^f	46.45 (37.15-52.55)
CD8+ T cell percentage (12.5-36.9%)^f	23.85 (16.58-31.33)
CD19+CD5+ B cell percentage (0-0.96%)^g	3.05 (0.955-7.818)
CD19+CD5- B cell percentage (1.45-9.49%)^g	11.13 (6.088-16.8)
Pulmonary function tests
% FVC (%)^h
% FEV1 (%)^h
% DLCO (%)^i

DM: dermatomyositis; ILD: interstitial lung disease; ANA: anti-nuclear autoantibodies; ARS: aminoacyl-tRNA synthetases; MDA-5: melanoma differentiation-associated gene-5; TIF1γ: transcription intermediary factor 1γ; NXP-2: nuclear matrix protein-2; Mi-2: nucleosome remodelling deacetylase complex; SAE: small ubiquitin-like modifier-1 activating enzyme; CK: creatine kinase; LDH: lactic dehydrogenase; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; IgG: immunoglobulin; %FVC: percent predicted forced vital capacity; %FEV₁: percent predicted forced expiratory volume in one second; %DL_CO: percent predicted carbon monoxide diffusion capacity. ^{a,b,c,d,e,f,g,h,i}Data were available for 149, 140, 142, 85, 144, 134, 118, 94, and 89 patients, respectively.