ASK1 Enhances Angiotensin II-Induced Liver Fibrosis <i>In Vitro</i> by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes

<div>Effects of an ASK1 inhibitor on Ang II-mediated proliferation and ECM-related protein expression in LX-2 cells. LX-2 cells were treated with Ang II alone or cotreated with Ang II and an ASK1 inhibitor (GS-4997). (a) Immunofluorescence images of <i>α</i>-SMA in LX-2 cells. (b) Cell viability was determined by the CCK-8 assay. (c) Quantitative real-time PCR and (d) western blotting were performed to measure the levels of <i>α</i>-SMA, Col I, and Col III expression in LX-2 cells. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: ASK1 Enhances Angiotensin II-Induced Liver Fibrosis <i>In Vitro</i> by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes 

Mediators of Inflammation

ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes

Figure 5