Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects

<div>Effects of repeated LPS injections and CLP on IBA1-positive cells. Immunohistochemistry showed increased intensity of IBA1-positive in the CA1 and CA3 following CLP, which were partially prevented by repeated LPS injections. 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169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> vs. CLP + Veh group. LPS: lipopolysaccharide; CLP: cecal ligation and puncture; Veh: vehicle; PFC: prefrontal cortex; CA1: cornu ammonis 1; CA3: cornu ammonis 3; DG: dentate gyrus. Red indicates IBA1; blue indicates DAPI; <span class="nowrap"><svg height="12.7373pt" id="M66" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -9.3079 98.3314 12.7373" width="98.3314pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M319 325C317 349 306 409 297 431C277 440 250 449 209 449C117 449 57 389 57 319C57 243 122 209 182 182C232 159 261 135 261 91C261 48 227 21 190 21C130 21 85 79 68 145L41 140C41 104 51 36 58 22C75 7 121 -12 172 -12C252 -12 337 35 337 126C337 195 286 231 210 262C166 281 126 304 126 348C126 388 152 417 191 417C240 417 274 378 294 318L319 325Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.875,0)"><path d="M390 111C344 68 312 56 269 56C212 56 118 102 118 241C118 346 175 401 241 401C277 401 312 388 342 360C350 352 355 349 361 349C372 349 394 371 394 392C394 403 391 411 378 422C362 436 329 449 288 449H287C250 449 190 432 138 392C71 341 37 274 37 197C37 90 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Mediators of Inflammation

fig7

Figure 7

Figure 7: Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects 