New Potential Weapons for Refractory Scleritis in the Era of Targeted Therapy

Table 2

Clinical characteristics and past treatments of 14 patients enrolled.

Patient	Age/sex	Anatomical pattern	Laterality	Systemic disease	Preceding biologics and their dose
1	42/M	Nodular AS	Bilateral	GPA	—
2	76/M	Necrotizing AS	Unilateral	MPA	—
3	66/M	Diffuse AS	Unilateral	RA	—
4	16/F	Posterior scleritis	Unilateral	Idiopathic	—
5	32/F	Diffuse AS	Unilateral	GPA	—
6	56/F	Diffuse AS	Bilateral	RA	ADA (40 mg/2 weeks), ABA (125 mg/week), IFX (5 mg/kg/4 weeks)
7	46/M	Diffuse AS	Unilateral	PsA	ADA 40 mg/2 weeks, IFX (5 mg/kg/4 weeks)
8	18/F	Posterior scleritis	Unilateral	Idiopathic	RTX (2 gr/6 months)
9	59/M	Nodular AS	Bilateral	RA	—
10	66/M	Posterior scleritis	Unilateral	FMF	—
11	54/F	Diffuse AS	Bilateral	RA	ADA (40 mg/2 weeks)
12	52/F	Diffuse AS	Unilateral	RA	—
13	34/F	Diffuse AS	Unilateral	RA	—
14	45/F	Diffuse AS	Bilateral	RA	ETN (50 mg/week), ADA (40 mg/2 weeks), TCZ (162 mg/week), RTX (2 gr/6 months)

ABA: abatacept; ADA: adalimumab; AS: anterior scleritis; F: female; GPA: granulomatosis with polyangiitis; IFX: infliximab; M: male; MPA: microscopic polyangiitis; PsA: psoriatic arthritis; RA: rheumatoid arthritis; RTX: rituximab; TCZ: tocilizumab.