High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury

Figure 5

ROS scavenging improves endothelial function in the MS model. SHR rats were fed a high-fat and high-glucose diet and administered oxonic acid (250 mg kg^-1 d^-1) and UA (250 mg kg^-1 d^-1) via intraperitoneal injection to generate a model of MS associated with hyperuricemia. (a) In the HUA group, the serum NO level was significantly decreased compared to that in the SHR group (). After administration of catalase, PEG-SOD, or epalrestat, the serum NO level of HUA rats increased remarkably. (b) Compared to the H₂O₂ level in SHR rats, the H₂O₂ level in MS model rats was significantly increased (), and treatment with catalase, PEG-SOD, or epalrestat decreased H₂O₂ generation (). (c) Compared to the TAC of SHR rats, the TAC of MS model rats was significantly decreased (); treatment with and catalase, PEG-SOD, or epalrestat increased H₂O₂ generation (). (d) vWF and (e) ET1 are two markers of endothelial injury. In the HUA group, the serum vWF and ET1 concentration was significantly increased compared to that in the SHR group (). After administration of catalase, PEG-SOD, or epalrestat, the serum vWF and ET1 concentration in HUA rats increased remarkably ().

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