Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy

Figure 2

Gemcitabine significantly attenuates IMQ-induced psoriasis-like skin inflammation. (a) The specific drug use scheme. (b) The skin lesions and H&E staining of the back skin derived from mice injected intraperitoneally with vehicle (IMQ+vehicle) or Gemcitabine (IMQ+GEM) or untreated (Normal) (one representative mouse from each group is presented, mice per group). Scale bars: 100 μm. Statistical analysis data is shown in (B). (c) The PASI score of mice in 3 groups. (d) The spleens and statistical analysis of the spleen index (mg/g) of mice among 3 groups. All results are representative of at least 3 independent experiments. , , , and ; ns: not significant. One-way ANOVA with Dunnett’s post hoc test was used.

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