Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway

Table 1

Effect of paeonol on the severity of histopathological lesions in methotrexate- (MTX-) induced cardiac toxicity in rats.

Groups	Myocardial necrosis	Hemorrhage	Inflammatory cell infiltration
Control	−	−	−
MTX	+++	++	+
Paeonol+MTX	+	+	+

Score level (−) is considered normal. Scores (+), (++), and (+++) are mild, moderate, and severe levels.