Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway

Table 2

Effect of paeonol on NADPH oxidase- (NOX-) 2, malondialdehyde (MDA), nitric oxide (NO), and reduced glutathione (GSH) levels along with superoxide dismutase (SOD) activity in methotrexate- (MTX-) induced cardiac toxicity in rats.

Groups	NOX-2 (ng/ml)	MDA (nmol/g tissue)	NO (nmol/g tissue)	GSH (nmol/g tissue)	SOD (U/g tissue)
Control
MTX	^a	^a	^a	^a	^a
Paeonol+MTX	^a,b	^b	^a,b	^a,b	^b

All parameters are expressed as of 6 observations. Significant difference is reported when . “a” means significant difference compared to the control group and “b” means significant difference compared to the MTX-treated group.