Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Figure 1

Ki20227 administration reduces microglia number. (a) Immunofluorescence staining images of Iba1 in the cortex of WT group and Ki20227-treated mice on days 7 and 14.  μm and 50 μm. Merged figure shows positive cells (white arrow). (b) Quantitative analyses of microglia density. WT group vs. Ki20227 administration on day 7, ; WT vs. Ki20227 administration on day 14, ; two-way ANOVA with Bonferroni’s posttest, . Data were presented as . (c) Quantitative analyses of weight changes after Ki20227 administration. Data were presented as . One-way ANOVA with Tukey’s tests, . No significant difference between WT and Ki20227 on day 7. WT vs. Ki20227 on day 14, .

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