Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Figure 2

TP and Ki20227 enhance behavioral function. (a) Graph represents the total time difference of experimental groups at pre-1 day, pre-2 days, and stroke rep-1 day. values were, respectively, pre-1 day, pre-2 days. and stroke-rep 1 day. Data were expressed as . No significant difference between the WT and WT+K groups; the WT group vs. WT+stroke group, ; the WT+stroke group vs. WT+stroke+TP group and WT+stroke+K group, ^#; the WT+stroke+K+TP group vs. WT+stroke+TP group and WT+stroke+K group, ^{^}. Data were presented as . Two-way ANOVA with Bonferroni’s posttest, . (b) Quantitative analyses of neurological score of experimental groups at 1 day after stroke. Data were expressed as . One-way ANOVA with Tukey’s tests, . The WT vs. WT+stroke and WT+K vs. WT+stroke+K groups, ; the WT+stroke vs. WT+stroke+TP and WT+stroke+K groups, ^###; and the WT+stroke+TP and WT+stroke+K vs. WT+stroke+K+TP, ^{^}.

(a)

(b)