Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Figure 7

TP and Ki20227 activate the Akt-Erk pathway. (a) Western blot images of BDNF, Akt, p-Akt, Erk1/2, and GADPH of experimental groups. Quantitative analyses of (b) Erk1/2 expression, (c) BDNF expression, and (d) p-Akt/Akt expression. Data were expressed as . One-way ANOVA with Tukey’s tests, . The WT vs. WT+stroke group and WT+K vs. WT+stroke+K group, ; the WT+stroke group vs. WT+stroke+TP group and WT+stroke+K group, ^#, ^##, ^###; and the WT+stroke+K+TP group vs. WT+stroke+TP and WT+stroke+K groups, ^{^^^}.

(a)

(b)

(c)

(d)