Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Figure 9

Illustrative mechanism following pretreatments with Ki2027 and TP in mouse model of ischemic stroke. The upregulation of BDNF, Erk1/2, and autophagy protein expressions contributed to neuronal recovery.