Mediators of Inflammation

Review Article

COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

Table 1

Interventional studies registered at the ClinicalTrials.gov database relating the treatment of COVID-19 with NET inhibitors.


NCT identifier	Status	Location	Study type	Condition or disease	Intervention and phase	Primary outcome	Estimated completion date

NCT04409925	Not yet recruiting	Canada	Nonrandomized pilot study	COVID-19	Dornase Alfa Phase: 1	(1) Rate of all adverse events	January 2021
NCT04359654	Not yet recruiting	United Kingdom	Randomized clinical trial	COVID-19 Hypoxia	Drug: Dornase Alfa Phase: 2	(1) Change in inflammation (C-reactive protein)	November 2020
NCT04445285	Recruiting	United States	Randomized clinical trial	COVID-19	Dornase Alfa Phase: 2	(1) All-cause mortality (2) Systemic therapeutic response	February 2021
NCT04432987	Recruiting	Turkey	Randomized clinical trial	COVID-19	Dornase Alfa Phase: 2	(1) Clinical improvement and inflammatory markers in blood (2) Intubation or extubation	September 2020
NCT04402944	Not yet recruiting	United States	Randomized clinical trial	COVID-19	Dornase Alfa Phase: 2	(1) Ventilator-free days	December 2021
NCT04322565	Recruiting	Italy	Randomized clinical trial	COVID-19 Pneumonia	Colchicine Phase: 2	(1) Clinical improvement (2) Hospital discharge	December 2020
NCT04326790	Recruiting	Greece	Randomized clinical trial	COVID-19	Colchicine Phase: 2	(1) Time to clinical deterioration (2) Concentration of cardiac troponin	September 2020
NCT04402970	Recruiting	United States	Nonrandomized clinical trial	COVID-19 ARDS	Dornase Alfa Phase: 3	(1) Improvement in partial pressure of O₂ to fraction of inspired O₂ ratio	May 2022
NCT04355364	Recruiting	France	Randomized clinical trial	COVID-19 ARDS	Dornase Alfa Phase: 3	(1) Occurrence of at least one grade improvement (ARDS scale severity)	August 2020
NCT04322682	Recruiting	United States	Randomized clinical trial	COVID-19	Colchicine Phase: 3	(1) Number of participants who die or require hospitalization	December 2020
NCT04328480	Recruiting	Argentina	Randomized clinical trial	COVID-19	Colchicine Phase: 3	(1) Number of participants who die (all-cause mortality)	August 2020

Retrieved October 30, 2020, from https://www.https://www.clinicaltrials.gov/ct2/home. Abbreviations: NCT: National Clinical Trial; O₂: oxygen; ARDS: acute respiratory distress syndrome.