Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammatory Response
SalD inhibited apoptosis induced by I/R injury in rats. (a) Representative TUNEL/NeuN immunofluorescence photograph. (b) The percent of TUNEL-positive cells. (c) The relative Bax/Bcl-2 ratio (). (d) The relative intensity of cleaved caspase-3 (). (e) The relative intensity of cleaved caspase-9 (). (f) The relative intensity of cytochrome c (). Proteins were acquired from the cerebral cortex region and assayed by the Western blot method. The intensity was normalized to β-actin. Data were expressed as .## versus the sham operation group; and versus the MCAO/R group. .
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