Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-<i>κ</i>B Activation to Inhibit Inflammatory Response

<div>SalD reduced the inflammatory response induced by I/R injury in rats. (a) SalD inhibited the astrocytes and microglia activation in I/R rats. Representative figures showing GFAP and Iba1 staining. (b) SalD downregulated the generation of TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 in I/R rats. (c) SalD attenuated the upregulated release of serum HMGB1 in I/R rats. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-<i>κ</i>B Activation to Inhibit Inflammatory Response 

Figure 3 | Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammatory Response 