Research Article
Anti-Inflammatory Profile of Jungia sellowii Less. by Downregulation of Proinflammatory Mediators and Inhibition of NF-κB and p38 Pathways
Table 2
Effects of the crude extract (CE) of Jungia sellowii Less., its derived fractions (aqueous (AqF), butanol (BuOHF), ethyl acetate (EtOAcF)), and isolated compounds (curcuhidroquinone O-β-glucose (CUR) and piptizol (Pip), myeloperoxidase, adenosine deaminase activity, and nitrite/nitrate concentrations) in the inflammation induced by carrageenan in the mouse model of pleurisy.
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Crude extract (CE: 50 mg/kg) of Jungia sellowii Less., aqueous fraction (AqF 25 mg/kg), butanol fraction (BuOHF 10 mg/kg), ethyl acetate fraction (EtOAcF: 10 mg/kg), curcuhidroquinone O-β-glucose (CUR: 2.5 mg/kg), and piptizol (Pip: 1 mg/kg) administered 0.5 h before pleurisy induction by carrageenan (1%). Sal: animals treated only with sterile saline solution (NaCl, 0.9%); Cg: animals treated only with carrageenan (1%); Dex: animals pretreated with dexamethasone (0.5 mg/kg); aadministered by intrapleural injection (i.pl.); badministered by intraperitoneal route (i.p.). Each group represents the of 5 animals compared to the positive control group (Cg); ANOVA/Newman-Keuls’s test. ; . |