Anti-Inflammatory Profile of Jungia sellowii Less. by Downregulation of Proinflammatory Mediators and Inhibition of NF-κB and p38 Pathways

Table 3

Effects of the crude extract (CE) of Jungia sellowii Less., its derived fractions (aqueous (AqF), butanol (BuOHF), and ethyl acetate (EtOAcF)), and isolated compounds (curcuhidroquinone O-β-glucose (CUR) and piptizol (Pip)), upon cytokine concentrations, in the inflammation induced by carrageenan in the mouse model of pleurisy.

Groups	Doses (mg/kg)	TNF-α (pg/mL) (% of inhibition)	IFN-γ (pg/mL) (% of inhibition)	IL-6 (pg/mL) (% of inhibition)	IL-12 (pg/mL) (% of inhibition)
Sal	0.9%^a
Cg	1%^a
CE	50^b	()	()	()	()
AqF	10^b	()	()	()	()
EtOAcF	10^b	()	()	()	()
BuOHF	10^b	()	()	()	()
CUR	2.5^b	()	()	()	()
Pip	1.0^b	()	()	()	()
Dex	0.5^b	()	()	7 ()	()

TNF-α: tumor necrosis factor alpha; IFN-γ: interferon gamma; IL-6: interleukin-6; IL-12: interleukin-12. Crude extract (CE: 50 mg/kg) of Jungia sellowii Less., aqueous fraction (AqF 25 mg/kg), butanol fraction (BuOHF: 10 mg/kg), ethyl acetate fraction (EtOAcF: 10 mg/kg), curcuhidroquinone O-β-glucose (CUR: 2.5 mg/kg), and piptizol (Pip: 1 mg/kg) administered 0.5 h before pleurisy induction by carrageenan (1%). Sal: animals treated only with sterile saline solution (NaCl, 0.9%); Cg: animals treated only with carrageenan (1%); Dex: animals pretreated with dexamethasone (0.5 mg/kg). ^aAdministered by intrapleural injection (i.pl.); ^badministered by intraperitoneal route (i.p.). Each group represents the of 5 animals compared to the positive control group (Cg); ANOVA/Newman-Keuls’s test. ; .