Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways

Figure 2

Histological findings of the colon (H&E). (a) Colon from the CNTR group (intact group). (b) Colon from the BER group (without ulceration rats). (c) Colon in experimental colitis, untreated group; tissue injury is characterized by severe mucosal damage with severe hemorrhage and infiltration of inflammatory cells. (d) Colon in BER low dose (25 mg/kg) and experimental colitis, treated group, showing reduced tissue injury. (e) Colon in BER high dose (50 mg/kg) and experimental colitis, treated group, showing the greatest reduction in the tissue injury characterized by less mucosal damage and low infiltration of inflammatory cells. All the images were taken at a 200x magnification.

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