Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways
MAPK inhibitors mediated the expression levels of cytokines and chemokines in IL-1β-stimulated ARPE-19 cells. ARPE-19 cells were treated with MAPK inhibitors (10 μM SB203580 (SB), 10 μM PD98059 (PD), or 10 μM SP600125 (SP)) with or without 10 μM luteolin and then incubated with IL-1β for 24 h. ELISA results showed the levels of (a) IL-6, (b) IL-8, (c) sICAM-1, and (d) MCP-1. Data represent the .,, compared to ARPE-19 cells stimulated with IL-1β alone. #,##, compared to IL-1β-stimulated ARPE-19 cells pretreated with only MAPK inhibitor.
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