Autophagy Contributes to Host Immunity and Protection against Zika Virus Infection via Type I IFN Signaling

Figure 1

(a) ZIKV-infected pregnant mouse model with different strains at PFU per mice. The viral burden in neonatal mice was detected using PFU assay the first day after birth. , data expressed as , . (b) Forebrain, midbrain, and hindbrain tissues of the neonatal mice infected with ZIKV-MR766 were sectioned for H&E staining. Arrows indicates the morphological changes. . (c) Hindbrain tissues were sectioned as above for immunostaining with CD11b, Ly6G, and other different antibodies to detect immune cells recruitment or infiltration in neonatal mice. . Data are shown as representative from 12 mice. (d) Statistic results of accumulated immune cells in each vision.

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