Research Article
ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis
Figure 8
ADAR1 regulates miR-30a biogenesis and SOCS3 expression in mouse sepsis model. In a murine sepsis model, Ad-O/E-ADAR1 was injected 24 h after induction, the whole spleen was harvested and lysed, and mRNA and protein were extracted. (a) Expression of ADAR1 and SOCS3 was measured by qRT-PCR and western blotting, and (b) pre-miR-30a and miR-30a-5p were measured by qRT-PCR. CLP vs. sham: , ; CLP+ADAR1 vs. CLP: , .
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