Monocyte/Lymphocyte Ratio and Cardiovascular Disease Mortality in Peritoneal Dialysis Patients

Table 2

Association between the baseline MLR tertiles and CVD mortality.

MLR	Model 1		Model 2		Model 3
	HR (95% CI)		HR (95% CI)		HR (95% CI)
Cox model
Lowest tertile	1.0		1.0		1.0
Middle tertile	1.24 (1.13-2.34)	0.013	1.19 (1.09-2.46)	0.030	1.13 (1.07-2.55)	0.037
Highest tertile	1.64 (1.16-2.32)	0.005	1.56 (1.15-2.44)	0.009	1.45 (1.13-2.51)	0.016
Competing risk
Lowest tertile	1.0		1.0		1.0
Middle tertile	1.22 (1.11-2.33)	0.014	1.16 (1.08-2.40)	0.032	1.10 (1.06-2.50)	0.039
Highest tertile	1.61 (1.15-2.30)	0.007	1.52 (1.14-2.43)	0.011	1.39 (1.10-2.47)	0.021
Competing risk^#
Lowest tertile	1.0		1.0		1.0
Middle tertile	1.18 (1.09-2.40)	0.017	1.14 (1.07-2.46)	0.037	1.09 (1.05-2.56)	0.040
Highest tertile	1.57 (1.13-2.36)	0.010	1.48 (1.11-2.49)	0.018	1.37 (1.09-2.54)	0.026

All-cause mortality as a competing risk. ^#Kidney transplantation or hemodialysis as a competing event risk. Model 1: unadjusted. Model 2: adjusted for age, sex, CCI, current smoking, current drinking, ACEI/ARB use, β-blocker use, and statin use. Model 3: model 2 adjusted for serum albumin, total cholesterol, triglycerides, LDL, HDL, serum uric acid, hs-CRP, NT-pro-BNP, and eGFR. CVD: cardiovascular disease; MLR: monocyte-to-lymphocyte ratio; CCI: Charlson comorbidity index; ACEI/ARB: angiotensin-converting enzyme inhibitor/angiotensin receptor blocker; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; NT-pro-BNP: N-terminal probrain natriuretic peptide; eGFR: estimated glomerular filtration rate.