Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced Arthritis

Figure 5

Relationship of ILCs and inflammation-associated cytokines in mice with CIA. (a) Serum levels of 18 cytokines (IFN-γ, IFN-β, TNF-α, MCP-1, GM-CSF, IL-1α, IL-1β, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-17A, IL-21, IL-22, IL-23, and IL-27) on day-0, week-1, week-2, week-3, week-4, and week-5. Each time point is the cytokine level in 7 to 10 mice. (b–d) Correlations of cytokines with the proportions ILC1, ILC2s, and ILC3s in the spleens of CIA mice. (b) Correlations of the proportion of ILC1s with IFN-γ, IL-12p70, IL-6, and IL-17A. (c) Correlations of the proportion of ILC2s with IL-4, IL-5, IL-9, IL-6, and IL-17A. (d) Correlations of the proportion of ILC3s in peripheral blood with IL-17A. Spearman’s rank correlation coefficients and values are indicated. IFN-γ: interferon-γ; TNF-α: tumor necrosis factor-α; MCP-1: monocyte chemoattractant protein-1; GM-CSF: granulocyte-macrophage colony-stimulating factor; IL: interleukin. .

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