Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis

Figure 2

Autoimmune vs. autoinflammatory responses in psoriasis. Complicate interactions between the innate and the adaptive immune systems characterize the pathophysiology of psoriasis. Once settled, the relative contribution of inflammatory and regulatory mediators of adaptive and innate immunity determines the clinical manifestation towards chronic stable vs. highly inflammatory and/or pustular psoriasis. Plaque psoriasis (psoriasis vulgaris) and generalized pustular psoriasis (psoriasis pustulosa) represent autoimmune (IL-17A/IFN-γ secretion profile) and autoinflammatory (IL-36/IL-1 secretion profile) response patterns, respectively.