Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis

Table 1

IL-1 family of ligands and receptors.

IL-1 family	Specific receptor	Coreceptor	Function
IL-1α, IL-1β	IL-1R1	IL-1RAP	Proinflammatory
IL-1β	IL-1R2	IL-1RAP	Anti-inflammatory
IL-1Ra	IL-1R1	Not available	Anti-inflammatory
IL-18	IL-18R1	IL-18RAP	Proinflammatory
IL-33	IL-1RL1	IL-1RAP	Proinflammatory
IL-36α, β, γ	IL-1RL2	IL-1RAP	Proinflammatory
IL-36Ra	IL-1RL2	IL-1RAP	Anti-inflammatory
IL-37	IL-18R1	SIGIRR	Anti-inflammatory
IL-38	IL-1RL2	IL-1RAPL2	Anti-inflammatory