The Value of the Systemic Immune-Inflammation Index in Predicting Survival Outcomes in Patients with Brain Metastases of Non-Small-Cell Lung Cancer Treated with Stereotactic Radiotherapy

Table 3

Univariate Cox regression analyses of the SII for OS and PFS in NSCLC patients with BM.

Parameters	OS		PFS
	HR (95% CI)	value	HR (95% CI)	value
Sex
Male	Reference	0.935	Reference	0.973
Female	0.980 (0.600-1.601)		0.992 (0.628-1.567)
Age (years)
<60	Reference	0.002	Reference	0.075
≥60	2.273 (1.343-3.845)		1.531 (0.959-2.447)
Smoking history
Never smoker	Reference	0.014	Reference	0.062
Smoker	1.982 (1.148-3.421)		1.579 (0.978-2.548)
KPS
90-100	Reference	0.021	Reference	0.275
70-80	1.837 (1.094-3.085)		1.295 (0.814-2.062)
Histology type
SCC	Reference	0.818	Reference	0.014
AD	1.067 (0.613-1.857)		2.100 (1.165-3.784)
Differentiation
Well/moderate	Reference	0.072	Reference	0.242
Poor	1.640 (0.956-2.814)		1.337 (0.822-2.175)
Primary site of tumor
Right	Reference	0.815	Reference	0.422
Left	0.944 (0.579-1.537)		1.206 (0.763-1.904)
Neurologic symptoms
No	Reference	0.209	Reference	0.652
Yes	0.730 (0.447-1.193)		0.900 (0.569-1.423)
Primary T stage
T1-T2	Reference	0.057	Reference	0.737
T3-T4	0.584 (0.336-1.016)		0.921 (0.571-1.488)
Primary N stage
N0-N1	Reference	0.344	Reference	0.946
N2-N3	0.761 (0.432-1.340)		0.983 (0.592-1.632)
Primary AJCC stage
I	Reference	0.045	Reference	0.299
II-III	1.689 (1.012-2.820)		1.276 (0.806-2.020)
No. of BM
1	Reference	0.680	Reference	0.798
2-3	0.899 (0.544-1.488)		0.941 (0.589-1.503)
Neutrophil
≤6.1	Reference	0.056	Reference	0.156
>6.1	1.894 (1.125-3.189)		1.452 (0.867-2.431)
Lymphocyte
≤3.5	Reference	0.521	Reference	0.658
>3.5	1.912 (0.263-13.879)		0.638 (0.087-4.671)
Platelet
≤169	Reference	0.506	Reference	0.129
>169	1.193 (0.709-2.009)		1.481 (0.892-2.457)
SII
≤480	Reference	0.006	Reference	<0.001
>480	2.196 (1.259-3.832)		2.471 (1.488-4.104)
NLR
≤2.5	Reference	0.336	Reference	0.343
>2.5	1.290 (0.768-2.167)		1.258 (0.783-2.021)
PLR
≤91.5	Reference	0.177	Reference	0.002
>91.5	1.456 (0.843-2.515)		2.360 (1.355-4.109)

Abbreviations: BM: brain metastasis; OS: overall survival; PFS: progression-free survival; HR: hazard ratio; CI: confidence interval; KPS: Karnofsky performance status; SCC: squamous cell carcinoma; AD: adenocarcinoma; SII: systemic immune-inflammation index; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio.