Mediators of Inflammation

Research Article

The Value of the Systemic Immune-Inflammation Index in Predicting Survival Outcomes in Patients with Brain Metastases of Non-Small-Cell Lung Cancer Treated with Stereotactic Radiotherapy

Table 4

Multivariate Cox regression analyses of the SII for OS and PFS in NSCLC patients with BM.


Parameters	OS		PFS
Parameters	HR (95% CI)	value	HR (95% CI)	value

Age (years)
<60	Reference	0.010
≥60	2.159 (1.205-3.869)
Smoking history
Never smoker	Reference	0.493
Smoker	1.233 (0.677-2.246)
KPS
90-100	Reference	0.018
70-80	1.887 (1.114-3.198)
Histology type
SCC			Reference	0.153
AD			1.690 (0.822-3.473)
Primary AJCC stage
I	Reference	0.939
II-III	1.023 (0.576-1.816)
SII
≤480	Reference	0.035	Reference	0.004
>480	1.938 (1.046-3.589)		2.224 (1.298-3.810)
PLR
≤91.5			Reference	0.392
>91.5			1.362 (0.671-2.766)

Abbreviations: BM: brain metastasis; OS: overall survival; PFS: progression-free survival; HR: hazard ratio; CI: confidence interval; KPS: Karnofsky performance status; SCC: squamous cell carcinoma; AD: adenocarcinoma; SII: systemic immune-inflammation index; PLR: platelet-to-lymphocyte ratio.