Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

<div>Overview of effects of SARS-CoV-2 infection on the muscle and bone. The SARS-CoV-2 infection elicits systemic inflammation (Cytokine storm), which activates the tryptophan-kynurenine pathway. Kynurenine is broken down into several downstream metabolites, which further activates AhR signaling, affecting the integrity and structure of the musculoskeletal system. (Figure is created by using <a href="http://BioRinder.com">http://BioRinder.com</a>.)</div>

Mediators of Inflammation

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Figure 2: Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview 