Mesenchymal Stem Cell-Derived Exosomes Modulate Chondrocyte Glutamine Metabolism to Alleviate Osteoarthritis Progression

Figure 6

Exosomes alleviate joint injury in OA rats. (a) The movement of mice on the treadmill. When all mice ran 37.69 meters, the number of electric shocks received by the mice was counted. (b) The cartilage was stained with HE. and 25 μm. (c) The cartilage was stained with safranin solid green staining. and 25 μm. (d) mRNA and protein expressions were detected by RT-qPCR and WB to detect TNFα and IL-6. (e) TUNEL assay was used to detect apoptosis. . (f) mRNA and protein expressions of collagen II and Aggrecan were detected by RT-qPCR and WB. (g) The expression of c-MYC and GLS1 was detected by IHC. and 25 μm. (h) mRNA and protein expressions of c-MYC and GLS1 were detected by RT-qPCR and WB. (i) α-KG content was detected by ELISA. vs. sham. ^## vs. OA.

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