Loss of GATA4 C-Terminus by p.S335X Mutation Modulates Coronary Artery Vascular Smooth Muscle Cell Phenotype

Figure 3

Deletion of GATA4 C-terminus did not alter RCSMC migration. Wound healing assay was adopted to observe the migratory rate of RCSMC. The quantitative analysis of wound healing assay was presented by the wound closure rate relative to the initial distance. Magnification: . (a, b) Representative images of migrated cells incubated with 10% FBS taken at 0 and 24 h after injury. One-way ANOVA, versus WT, . (c–k) Representative images of migrated cells stimulated by TNF-α (10 or 30 ng/ml) taken at 0, 10, and 24 h after injury. One-way ANOVA, versus WT, .

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