Research Article

Development an Inflammation-Related Factor-Based Model for Predicting Organ Failure in Acute Pancreatitis: A Retrospective Cohort Study

Table 2

Characteristics of enrolled patients.

VariableNOF ()OF ()

Age (years) ()0.774
Sex, male/female33/467/80.821
Time of onset (hours)0.705
 0-24 h287
 24-48 h274
 48-72 h244
Etiology0.417
 Biliary, (%)4311
 Alcohol, (%)82
 Hypertriglyceridemia, (%)131
 Other, (%)151
APPACHE II score0.011
RANSON score<0.001
Length of hospital stay (days)9 (7, 12)16 (15, 36)-4.06<0.001
Hospital cost (CNY)32435 (22203, 41689)75075 (62198, 174771)<0.001
Inflammatory markers (pg/mL)Median (P25, P75)Median (P25, P75)
 IL1a2.35 (1.55, 4.25)1.55 (1.28, 2.56)-1.760.474
 IL1b3.32 (1.73, 8.18)3.16 (1.69, 11.38)-0.030.895
 IL42.33 (1.42, 4.75)2.08 (1.57, 3.67)-0.490.431
 IL624.43 (10.18, 42.3)106.9 (78.97, 188.13)-4.82<0.001
 IL84.52 (2.99, 7.86)14.14 (5.68, 18.03)-3.760.002
 IL101.51 (0.83, 2.62)8.25 (4.33, 14.98)-4.670.003
 IL130.58 (0.32, 0.76)0.31 (0.2, 0.65)-1.360.348
 MCP1152.64 (125.18, 192.46)234.11 (165.02, 280.94)-1.010.001
 IFNg1.56 (0.93, 2.49)1.21 (0.78, 2.24)-2.710.505
 TNFa5.78 (2.34, 11.16)4.4 (2.2, 11.55)-0.450.624
 PCT (ng/mL)0.42 (0.12, 1.18)2.07 (0.33, 23.38)-2.65<0.001
 CRP (mg/mL)90 (40.1, 90)90 (84.9, 90)-1.020.84
Routine blood test
 WBC, ×109/L ()0.244
 LY, ×109/L median (P25, P75)1.13 (0.85, 1.57)0.99 (0.85, 1.25)-1.1720.241
 MO, ×109/L median (P25, P75)0.53 (0.44, 0.78)0.45 (0.34, 0.95)-0.7490.454
 NE, ×109/L ()0.161
Immunity markers (%)
 CD3 T lymphocytes0.002
 CD3CD4 T lymphocytes0.007
 CD3CD8 cytotoxic T lymphocytes23.06 (17.56, 28.53)21.56 (13.21, 26.84)-1.10.272
 CD16+ CD56+ natural killer cells10.9 (6.7, 18.39)14.67 (7.63, 17.39)-0.490.624
 CD19+ B lymphocytes14.5 (10.2, 19.8)25.57 (17.9, 29.97)-3.929<0.001
 CD4CD8 cytotoxic T lymphocytes1.76 (1.29, 2.24)1.55 (1.09, 2.87)-0.0830.934

CNY (Chinese Yuan), white blood cell counts (WBC), lymphocyte (LY), neutrophils (NE), and monocyte (MO).