Investigation of Newly Diagnosed Drug-Naive Patients with Systemic Autoimmune Diseases Revealed the Cleaved Peptide Tyrosine Tyrosine (PYY 3-36) as a Specific Plasma Biomarker of Rheumatoid Arthritis

Figure 4

The concentrations of plasma cytokines (pg/ml) in the ascending order of (a) RA (), (b) SLE (), and (c) SSc () patients versus age- and gender-matched healthy controls () measured by the Luminex MAGPIX technology. The cleaved peptide tyrosine tyrosine PYY (3-36) is a novel marker of early-onset therapy-naive rheumatoid arthritis (RA) (). The arithmetic are demonstrated for each cytokine on a log10 scale in GraphPad Prism software. The connecting lines delineate a characteristic pattern of proteins measured specific to drug-naive autoimmune diseases (red) such as (a) RA, (b) SLE, and (c) SSc or healthy controls (green).

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