Research Article

Investigation of Newly Diagnosed Drug-Naive Patients with Systemic Autoimmune Diseases Revealed the Cleaved Peptide Tyrosine Tyrosine (PYY 3-36) as a Specific Plasma Biomarker of Rheumatoid Arthritis

Table 1

The summary of the significant differences of plasma cytokine concentrations between drug-naive autoimmune patients (RA, SLE, SSc) and healthy controls (HCs) in a pairwise comparison. The arithmetic means (mean), standard deviation (SD), and the standard error of the mean (SEM) of the plasma cytokine concentrations were calculated. The pairwise comparison of the concentrations of each cytokine of patients versus healthy controls (RA vs. HC; SLE vs. HC; SSc vs. HC) was carried out by one-way ANOVA (; , ). The 95% confidence intervals (CI, 95%) were calculated between patients and HCs for each cytokine separately. Italic emphasis corresponds to overlapping patient’s CI with HCs.

CytokineCohortMean (pg/ml)SDSEMOne-way ANOVA ()CI (95%)

IL-12p40HC4.182.850.459.7-053.30-5.06
RA8.906.451.166.63-11.17

IL-10HC4.964.660.743.2-023.51-6.40
RA12.0219.693.545.09-18.95

IL-13HC7.2515.532.469.7-052.43-12.06
RA41.7449.748.9324.23-59.25

IFN-γHC23.6418.352.901.6-0217.96-29.33
RA98.83191.0334.3131.58-166.07

M-CSFHC27.3434.095.394.8-0216.78-37.91
RA100.58227.0140.7720.66-180.49

IL-4HC31.1469.4410.981.7-039.62-52.66
RA121.79157.0728.2166.50-177.09

NTproBNPHC39.2447.077.4424.64-53.82
RA142.07194.6634.961.9-0373.55-210.59

IL-17AHC15.9826.994.273.5-037.62-24.34
RA154.17288.1351.7552.74-255.6

BMP-9HC37.7834.565.462.9-0227.07-48.49
RA160.67347.6962.4538.27-283.06

PYYHC163.9691.6814.504.0-05135.55-192.37
RA361.60265.7747.73268.05-455.16

GITRLHC110.19100.9415.961.4-0378.91-141.47
RA901.221498.96269.22373.54-1428.89

MMP-12HC154.26278.2043.997.4-0368.05-240.48
RA833.001525.20273.93296.09-1369.91

TNFRSF6HC209.45574.0990.773.9-0331.54-387.36
RA1200.631998.27358.90497.18-1904.07

IL-12p40HC4.182.850.455.7-063.29-5.06
SLE10.867.431.707.52-14.20

M-CSFHC27.3434.095.396.8-0316.77-37.90
SLE63.0663.9414.6734.31-91.81

IL-4HC31.1469.4410.985.2-029.61-52.65
SLE70.1673.0316.7537.32-102.99

GITRLHC110.19100.9415.961.3-0278.90-141.47
SLE217.58222.5651.06117.50-317.65

NTproBNPHC39.2447.077.441.9-0224.64-53.82
SLE315.89727.91166.991.69-643.19

NTproBNPHC39.23547.077.443.8-0324.64-53.82
SSc174.206272.7686.255.15-343.26

PYYHC163.960591.6814.503.1-02135.54-192. 37
SSc232.96268.1221.54190.73-275.18

MMP-12HC154.2605278.2043.992.1-0268.04-240.47
SSc514.748798.52252.5219.82-1009.66