Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance

Figure 1

Role of EVs in placenta and pregnancy disorders. EVs mainly include exosomes and particles, which can be derived from stem cells, tumor cells, immune cells, and placental tissue cells. They participate in intercellular communication by transmitting bioactive proteins, lipids, and nucleotides to targeted cells. EVs, especially EVs derived from placental tissue cells, play a crucial role in regulating inflammation, autoimmune, tumor occurrence, and placental microenvironment balance. EVs have been used to prevent pregnancy diseases such as PE, fetal growth restriction, and spontaneous abortion.