Involvement of circRNAs in Proinflammatory Cytokines-Mediated β-Cell Dysfunction

Figure 2

Validation for the expression of four dysregulated circRNAs. (a) The four dysregulated circRNAs were selected and shown with fold changes, values, and genomic locations. (b) The expression of the four selected circRNAs were changed by proinflammatory cytokines. MIN6 cells were incubated in the absence or presence of 2.5 ng/mL IL-1β, 2.5 ng/mL TNF-α, and 25 ng/mL IFN-γ (24 h incubation). The expression levels were measured by qRT-PCR. The results are shown as for three independent experiments. , compared with control group.

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