Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

Figure 1

Effect of PQ on the expression of TOLLIP, TLR2, and TLR4 in the rat kidney tissues. Wistar rats received 25 mg/kg PQ via intraperitoneal injection. (a) The mRNA expression of TOLLIP, TLR2, and TLR4 in the kidney tissues at 3, 6, 12, and 24 h post-PQ treatment. (b) Representative images of H&E staining of the kidney tissues at 24 h post-PQ treatment (red asterisk, degenerative renal tubules; black arrow, necrosis; yellow arrow, degenerative glomerulus; and green double arrowhead, hemorrhage). (c, d) Representative images of TLR2-TOLLIP and TLR4-TOLLIP staining of the kidney tissues at 24 h post-PQ treatment. , , and ().

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