Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

Figure 2

Effect of TOLLIP knockdown on the PQ-induced AKI in rats. Wistar rats were infected with the AV carrying shTOLLIP via tail vein injection and then treated with 25 mg/kg PQ via intraperitoneal injection 48 h post-AV infection. (a, b) The mRNA and protein expression of TOLLIP in the kidney tissues at 24 h post-PQ treatment. (c) The level of BUN and creatinine in the serum at 24 h post-PQ treatment. (d) Representative images of H&E staining of the kidney tissues at 24 h post-PQ treatment. (e) Representative images of cleaved caspase-3 immunofluorescence staining of the kidney tissues at 24 h post-PQ treatment. and ().

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