Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

Figure 6

Role of the NF-κB pathway in the TOLLIP-induced inhibition of NLRP3 inflammasome activation in PQ-treated HK-2 cells. HK-2 cells were infected with the AV carrying shTOLLIP and then treated with 300 μM PQ and 5 μM BAY11-7082 48 h post-AV infection. (a) The level of IL-18 and IL-1β at 24 h post-PQ and BAY11-7082 treatment. (b) The protein expression of NLRP3, pro-caspase-1, and caspase-1 at 24 h post-PQ and BAY11-7082 treatment. and ().

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