Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells

Figure 4

NKT cell-mediated transactivation. Following antigen presentation, NKT cells rapidly produce high levels of IFN-γ or IL-4. IFN-γ-producing NKT1 cells promote the lytic activity of CD8⁺ lymphocytes and NK cells and the production of IgE and IgG in B lymphocytes. On the other hand, IL-4-producing NKT2 cells promote the production of IL-12 and IL-18 in APCs, the production of IgE and IgG in B lymphocytes, and the production of IFN-γ and capacity for specific antigen recognition in CD4⁺ T lymphocytes. APCs, antigen-presenting cells; CD, cluster of differentiation; IFN, interferon; Ig, immunoglobulin; IL, interleukin; NK, Natural Killer cell; NKT, Natural Killer T cell; TCR, T-cell receptor. (Created with http://BioRender.com).