Review Article
The Emerging Roles of CCN3 Protein in Immune-Related Diseases
Table 1
Immune-related diseases influenced by CCN3.
| Diseases | Mechanisms |
| Osteoarthritis (OA) | Decreases MMP, reduces extracellular matrix catabolism, and decreases the level of proinflammatory cytokines | Glomerulonephritis (GN) | Antifibrosis, inhibits mesangial cell growth, and inhibits the acceleration of ECM | Metabolic diseases | Inhibits the proliferation of pancreatic β-cells, regulates macrophage function, and regulates insulin signaling | Multiple sclerosis (MS) | Regulates Treg function and promotes myelin regeneration | Systemic sclerosis (SSc) | Antifibrosis, proangiogenesis, and controls extracellular matrix deposition | Rheumatoid arthritis (RA) | Decreases inflammatory cytokines |
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