EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury

Figure 1

The inflammation, glycolysis, and HIF-1α in microglia treated with LPS were associated with upregulated EZH2. In the control group and LPS group. (a) qRT-PCR detected EZH2 expression. (b) qRT-PCR was performed to detect the expression of HIF-1α. (c) The expressions of inflammatory factors IL-6, TNF-α, and IL-17 were detected by qRT-PCR. (d) qRT-PCR detected glycolysis-related gene PKM2, GLUT1,and HK2 expressions. (e) Western blot analysis of the expression of EZH2; HIF-1α; inflammatory factors IL-6, TNF-α, and IL-17; and glycolysis-related genes PKM2, GLUT1, and HK2. vs. Control group.

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