Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis

Figure 2

TL1A promotes colon inflammation in the DSS-induced intestinal fibrosis model. Transgenic (Tg) and wildtype (WT) mice were subjected to 2.0% dextran sulfate sodium (DSS) to generate an intestinal fibrosis model. There were four study groups: control/WT group (), control/Tg group (), DSS/WT group (), and DSS/Tg group (). (a) The percent change in body weight of mice during modeling. (b) Postmodeling disease activity index (DAI) based on body weight, stool characteristics, and fecal occult blood of mice. (c, d) Macroscopic damage and score. (e) Weight of colon. (f) Length of colon. (g) Colon weight/length ratio. (h) Representative images of H&E-stained colonic tissue sections of WT and Tg mice (100x). (i) Microscopic damage score. (j) Myeloperoxidase (MPO) activity. Data were given as (SD). As compared to the control group: , , and .

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