Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation

<div>MTA1 interacted with HDAC1 and promoted HDAC1 expression. (a) The interaction between MTA1 protein and HDAC1 protein was verified by Co-IP assay. (b–d) pcDNA-MTA1, si-MTA1, and their negative controls were transfected into MH7A cells, respectively. The expression of MTA1 and HDAC1 was measured by Western blot analysis. (e, f) TNF-<i>α</i>-treated MH7A cells were treated with 50 <i>μ</i>M EA alone or together with pcDNA-MTA1. The expression of HDAC1 was measured by Western blot analysis. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation 