Research Article
Interleukin-22 Plays a Protective Role by Regulating the JAK2-STAT3 Pathway to Improve Inflammation, Oxidative Stress, and Neuronal Apoptosis following Cerebral Ischemia-Reperfusion Injury
Figure 7
JAK2 and STAT3 knockdown abolished IL-22-mediated neuroprotection. The mRNA expression of IL-1β (a), MCP-1 (b), and TNF-α (c) was detected in PC12 cells (). The levels of SOD (d), GSH (e), and MDA (f) were detected in PC12 cells (). (g) The expression of Bax, Bcl-2, and β-actin was detected by western blotting (). vs. PBS group; # vs. OGD/R group; & vs. OGD/R+rIL-22 group.
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