IL-9 and IL-10 Single-Nucleotide Variants and Serum Levels in Age-Related Macular Degeneration in the Caucasian Population
Table 2
Distributions of IL-9 and IL-10 SNP genotypes and alleles in the early, exudative, and atrophic AMD and control groups.
SNP
Genotypes/alleles
Group
value
value
value
Early AMD (), (%)
Exudative AMD (), (%)
Atrophic AMD (), (%)
Control (), (%)
IL-9 rs1859430
GG
225 (65.6)
262 (62.1)
33 (54.1)
233 (60.8)
0.024
0.871
0.426
GA
95 (27.7)
143 (33.9)
24 (39.3)
136 (35.5)
AA
23 (6.7)
17 (4.0)
4 (6.6)
14 (3.7)
G
545 (79.4)
667 (79.0)
90 (73.8)
602 (78.6)
0.625
0.472
0.088
A
141 (20.6)
177 (21.0)
32 (26.2)
146 (21.4)
IL-9 rs2069870
AA
222 (64.7)
262 (62.1)
33 (54.1)
235 (61.4)
0.349
0.832
0.282
AG
121 (35.3)
160 (37.9)
28 (45.9)
148 (38.6)
GG
0 (0)
0 (0)
0 (0)
0 (0)
A
565 (82.4)
684 (81.0)
94 (77.0)
618 (80.7)
0.410
0.853
0.350
G
121 (17.6)
160 (19.0)
28 (23.0)
148 (19.3)
IL-9 rs11741137
CC
238 (69.4)
290 (68.7)
41 (67.2)
247 (64.5)
0.117
0.389
0.846
CT
91 (26.5)
120 (28.6)
18 (29.5)
126 (32.9)
TT
14 (4.1)
12 (2.8)
2 (3.3)
10 (2.6)
C
657 (82.7)
700 (82.9)
100 (82.0)
620 (80.9)
0.053
0.297
0.788
T
119 (17.3)
144 (17.1)
22 (18.0)
146 (19.1)
IL-9 rs2069885
GG
240 (70.0)
293 (69.4)
41 (67.2)
250 (65.3)
0.172
0.453
0.892
GA
90 (26.2)
119 (28.2)
18 (29.5)
123 (32.1)
AA
13 (3.8)
10 (2.4)
2 (3.3)
10 (2.6)
G
570 (83.1)
705 (83.5)
100 (82.0)
623 (81.3)
0.382
0.24
60.867
A
116 (16.9)
139 (16.5)
22 (18.0)
143 (18.7)
IL-9 rs2069884
GG
239 (69.7)
292 (69.2)
41 (67.2)
250 (65.3)
0.199
0.495
0.892
GT
91 (26.5)
120 (28.4)
18 (29.5)
123 (32.1)
TT
13 (3.8)
10 (2.4)
2 (3.3)
10 (2.6)
G
569 (82.9)
704 (83.4)
100 (82.0)
623 (81.3)
0.424
0.273
0.867
T
117 (17.1)
140 (16.6)
22 (18.0)
143 (18.7)
IL-10 rs1800871
GG
208 (60.6)
252 (59.7)
38 (62.3)
232 (60.6)
0.705
0.903
0.957
GA
123 (35.9)
152 (36.0)
20 (32.8)
133 (34.7)
AA
12 (3.5)
18 (4.3)
3 (4.9)
18 (4.7)
G
539 (78.6)
656 (77.7)
96 (78.7)
597 (77.9)
0.770
0.918
0.852
A
147 (21.4)
188 (22.3)
26 (21.3)
169 (22.1)
IL-10 rs1800872
GG
208 (60.6)
252 (59.7)
38 (62.3)
232 (60.6)
0.705
0.903
0.957
GT
123 (35.9)
152 (36.0)
20 (32.8)
133 (34.7)
TT
12 (3.5)
18 (4.3)
3 (4.9)
18 (4.7)
G
539 (78.6)
656 (77.7)
96 (78.7)
597 (77.9)
0.770
0.918
0.852
T
147 (21.4)
188 (22.3)
26 (21.3)
169 (22.1)
IL-10 rs1800896
TT
103 (30.0)
112 (26.5)
14 (23.0)
103 (26.9)
0.642
0.319
0.084
TC
175 (51.0)
207 (49.1)
27 (44.3)
203 (53.0)
CC
65 (19.0)
103 (24.4)
20 (32.8)
77 (20.1)
T
381 (55.5)
431 (51.1)
55 (45.1)
409 (53.4)
C
305 (44.5)
413 (48.9)
67 (54.9)
357 (46.6)
0.413
0.350
0.088
Early AMD vs. control group. Exudative AMD vs. control group. Atrophic AMD vs. control group. : significance level and Bonferroni corrected significance level when .
