IL-9 and IL-10 Single-Nucleotide Variants and Serum Levels in Age-Related Macular Degeneration in the Caucasian Population

Table 7

Haplotype association with the predisposition to AMD occurrence.

	SNP1	SNP2	SNP3	SNP4	SNP5	SNP6	SNP7	SNP8	Frequency	OR (95% CI)	value
Haplotype associations with early AMD
1	G	A	C	G	G	—	—	—	0.7715	1	—
2	A	G	T	A	T	—	—	—	0.1468	0.76 (0.54-1.08)	0.13
3	A	G	C	G	G	—	—	—	0.0335	0.49 (0.25-0.95)	0.035
4	A	A	T	A	T	—	—	—	0.018	1.74 (0.72-4.22)	0.22
5	G	A	T	A	T	—	—	—	0.0108	0.08 (0.01-0.61)	0.015
6	A	A	C	G	G	—	—	—	0.0103	2.25 (0.66-7.66)	0.19
7 (rare)						—	—	—	0.009	1.29 (0.32-5.21)	0.72
8	—	—	—	—	—	G	G	C	0.4549	1	—
9	—	—	—	—	—	G	G	T	0.3275	1.13 (0.89-1.44)	0.31
10	—	—	—	—	—	A	T	T	0.2166	1.00 (0.75-1.32)	0.98
11 (rare)	—	—	—	—	—				0.001	<0.001 (-)	1
Haplotype associations with exudative AMD
1	G	A	C	G	G	—	—	—	0.7713	1	—
2	A	G	T	A	T	—	—	—	0.1487	0.96 (0.69-1.35)	0.83
3	A	G	C	G	G	—	—	—	0.0408	0.99 (0.57-1.73)	0.98
4	A	A	T	A	T	—	—	—	0.0165	1.11 (0.46-2.66)	0.82
5 (rare)						—	—	—	0.0227	0.37 (0.15-0.92)	0.033
6	—	—	—	—	—	G	G	C	0.4751	1	—
7	—	—	—	—	—	G	G	T	0.3026	0.87 (0.68-1.10)	0.24
8	—	—	—	—	—	A	T	T	0.2205	0.94 (0.72-1.22)	0.63
9 (rare)	—	—	—	—	—				0.0018	0.34 (0.02-5.66)	0.45
Haplotype associations with atrophic AMD
1	G	A	C	G	G	—	—	—	0.7558	1	—
2	A	G	T	A	T	—	—	—	0.1518	1.25 (0.65-2.40)	0.5
3	A	G	C	G	G	—	—	—	0.0453	2.34 (0.93-5.88)	0.071
4	G	A	T	A	T	—	—	—	0.0167	<0.00 (-)	1
5	A	A	T	A	T	—	—	—	0.0162	1.05 (0.23-4.68)	0.95
6 (rare)						—	—	—	0.0142	0.55 (0.07-4.43)	0.57
7	—	—	—	—	—	G	G	C	0.4758	1	—
8	—	—	—	—	—	G	G	T	0.3046	0.62 (0.38-1.02)	0.06
9	—	—	—	—	—	A	T	T	0.218	0.78 (0.47-1.29)	0.33
10 (rare)	—	—	—	—	—				0.0016	<0.00 (-)	1

Rare: pooled rare haplotypes; OR: odds ratio; CI: confidence interval; p: significance level when ; SNP1: rs1859430; SNP2: rs2069870; SNP3: rs11741137; SNP4: rs2069885; SNP5: rs2069884; SNP6: rs1800871; SNP7: rs1800872; SNP8: rs1800896.