A Cornflower Extract Containing <i>N</i>-Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX

<div>(a) Human COX-2 (PDB 5KIR) with docked <i>N</i>-feruloylserotonin in the active site shown as green surface. The heme group is depicted as red stick model. The three-pocket entry-restricting residues Arg120, Glu524, and Tyr355 surround the docked ligand as stick models. (b) Binding hypothesis of <i>N</i>-feruloylserotonin to COX-2 (docking score -11.41 kcal/mol). Protein-ligand interactions are indicated as blue dashed lines for aromatic interactions and yellow dashed lines for hydrogen bonds. Tyr385 has been shown to be actively involved in electron transfer between natural substrate arachidonic acid and heme [<a href="/journals/mi/2021/6652791/#B60">60</a>].</div>

Mediators of Inflammation

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Figure 8

Figure 8: A Cornflower Extract Containing <i>N</i>-Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX 

Figure 8 | A Cornflower Extract Containing N-Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX 